Since the blue pill (Viagra) came out, old men seem to live more and more confidently, and it seems that it is no longer a myth to be a living dragon after 60 years old. In fact, Viagra belongs to the so-called type 5 phosphodiesterase inhibitor (PDE5-I) and is currently the oral drug of choice for the treatment of male sexual dysfunction. With other pharmaceutical companies developing new drugs to join the competition, PDE5-I is currently circulating in the market. Besides Viagra, there are Letra and Cialis. There are some differences in dosage and drug activity among them, but all of them can treat sexual dysfunction, but patients must take drugs before sex as needed, and the effect can reach 60% to 70%.The above conclusions show that 犀利士16mg To a great extent, it can bring new vitality to the market and make the industry develop well. https://www.cialis-hk.cn
However, it is gradually pointed out in the literature that some patients with impotence, such as patients with sexual nerve damage after prostate surgery, diabetics, or patients with severe poor vascular activity, are ineffective in treating impotence with PDE 5-I. On the other hand, according to statistics, 35-47% of patients will stop taking PDE5-I ondemand feel it is effective, but only use drugs when necessary. In fact, it is still impossible for patients (40-50%) to completely restore their “normal” sexual life, because planned sexual behavior may cause anxiety and affect their performance.
The researchers found that long-term administration of PDE5Inhibitor can reduce the cell decay of smooth muscle in cavernous tissue and the disability of vascular endothelial cells in patients with impotence due to bilateral nerve damage after prostatectomy. In the experimental model of mice and animals, it was also found that rats in the experimental group could slow down the fibrosis of cavernous tissue, avoid the loss of smooth muscle of cavernous body, and stimulate the production of NO after 45 days of long-term continuous feeding with Viagra 20mgkg. In this way, more and more documents have confirmed that the treatment of sexual dysfunction is at least as good or better than that of continuous daily use of PDE5-I and on-demand use of PDE5-I, and it is also beneficial to the overall human vascular health. Among the drugs listed above, the half-life of Sharp is as long as 175 hours and the reaction time is as long as 36 hours, which makes it possible to maintain a certain drug concentration in the human body by using a low dose every day. After five days of oral administration of 5mg of Sharp, the concentration in the body can reach 16 times that of single use, so it can effectively treat organic sexual dysfunction. In McMahon’s research, after 26 weeks’ continuous use of 20mg Sharp ondemand and 10mg Sharp every day, it was found that the latter can effectively maintain the improved erectile function compared with the former in the field of IIEFEF (sexual habit evaluation index). In further clinical trials, the efficacy of giving Sharp 5mg once a day is the same as that of clinical trials using Sharp 10mg or 20mg as needed. The tolerance of patients taking 5mg daily tablets of Sharp is the same as that of clinical trials using 10mg or 20mg of Sharp as required.
Therefore, the daily tablet of Sharp has become the only PDE5-I drug approved by the Department of Health for sustainable daily use. The advantage is that long-term use can improve the function of endothelial cells, and the incidence of side effects may be low. For patients who have been diagnosed to have to use PDE5-I to treat sexual dysfunction, if the patient wants to restore more “natural” sexual behavior, daily use of tablets can break the expected anxiety of sexual behavior before taking medicine. Clinical data also confirmed that using Sharp once a day is usually well tolerated. At present, there is no evidence of drug resistance or resistance to treatment.
Safety assessment
At present, there are not many related research results. The known results show that there is not much difference in the types and incidence of side effects between low-dose daily tablets of Sharp and ondemand. The most commonly reported side effects are indigestion, headache, back pain and symptoms suspected of catching a cold.
Absolute taboo
Like all PDE5-I, Sharp is prohibited for patients who use any form of organic nitrate. If it is necessary to give nitrate drugs, it must be at least 48 hours apart and closely monitored by medical staff through proper hemodynamic monitoring. In addition, Sharp is also prohibited for patients who have lost their monocular vision due to non-arterial anterior ischemic optic neuropathy (NAION).
conclusion
The history of human beings using PDE5-I to treat sexual dysfunction has entered the second decade. More and more clinicians have found that a single use of PDE5-I drugs to achieve the purpose of erection is actually not a complete success in treating sexual dysfunction, because patients want to restore their former glory and do it if they want, rather than taking medicine to complete planned sexual behavior. In fact, different needs and ideas of individuals must be considered in the treatment of impotence, but the current research results often cannot answer these complicated questions. If the patient wants to restore more “natural” sexual behavior, after the professional evaluation of doctors, it may be a new opportunity to treat impotence by continuing to use daily tablets of Sharp.
