Many people have tried the daily spindle jump of Sharp, but they often don’t know the use principle and precautions. Now I will share with you the use and use principle of tadalafil. In addition, the public is also reminded that the use of such drugs must consult a specialist and do not take drugs indiscriminately.Therefore, 犀利士哪裡買 Only then will more and more pump owners cheer for it and spread the value and function of the brand. https://www.cialis-hk.cn
1. What is the difference between Sharp’s 5mg and 10mg and 20mg?
Everyone must want to say, it’s true that the dosage is different, but taking 5 mg of tadalafil every day is different from taking 5 mg once. When the dose range of healthy subjects is 25 to 20 mg, the exposure (AUC) and dose of tadalafil are linear (as shown in the figure below), but tadalafil has slow metabolism and long half-life (175 hours), so it is additive to take it daily. Studies have shown that the plasma concentration can reach a stable state within 5 days after taking 5 mg of tadalafil daily, and the exposure at this time is about 16 times that after a single dose of the drug, in short, compared with a single dose of 8 mg.
As can be seen from the following figure, after a single oral administration, the maximum plasma concentration (Cmax) takes place 30 minutes to 6 hours after administration (the median is 2 hours), so tadalafil recommends taking it at least 30 minutes to 2 hours in advance. If you take 5 mg a day, you can keep the relative benefit of 8 mg in your blood at any time, saving the time for the drug effect to play. On the other hand, from the perspective of side effects, the higher the dosage, the higher the proportion of side effects, so it is generally recommended to supplement from a lower dosage.
Second, the sharp Tadalafil5 mg use precautions
Many people must have been puzzled. If you take daily tablets of Sharp, can you use higher units of tablets or sildenafil when necessary? The answer depends on the dose. According to the pharmacokinetics of tadalafil, the plasma concentration can reach a stable state by taking 5 mg every day for 5 days. At this time, the blood concentration is about 8 mg, so if necessary, Tadalafil10 mg can still be supplemented 30 minutes before sexual intercourse. In addition, studies have shown that under the condition of taking tadalafil5 mg daily, it is better to use sildenafil 50 mg to improve erectile function when needed, and the incidence of side effects has not increased, indicating that it is safe to use both when needed.
? ? As we all know, the combination of tadalafil and nitroglycerin may lead to the decrease of blood pressure and even cause danger, so it is forbidden to use it together. But if it is possible to use it together, how long will it take before it will affect blood pressure? The drug copy clearly points out that if the interval between them is more than 48 hours, it is unlikely to cause blood pressure changes. In addition, another common cause of hypotension is “alcohol”. In fact, alcohol itself is a mild vasodilator. If you drink more than 5 units of alcohol and take tadalafil, it will increase the incidence of signs and symptoms of orthostatic hypotension, including rapid heartbeat, decreased blood pressure when standing, dizziness and headache.
Generally speaking, renal function is so severe that creatinine clearance rate <: 30mLmin, or people with the following cardiovascular diseases, it is not recommended to take Sharp Daily Ingots.
(1) Patients with myocardial infarction in the last 90 days
(2) Patients with unstable angina pectoris or angina pectoris during sexual intercourse.
(3) Patients with heart failure classified as Grade II or above by new york Heart Association in the last 6 months.
(4) The patient has uncontrolled arrhythmia and low blood vessels (<: 9050 mm Hg), or uncontrolled hypertension.
(5) Patients with stroke in the last 6 months.
[Note” target=_blank> One unit of alcohol = three cans (about 250 ml) of beer with 5% alcohol content.
A small glass (about 100ml) of wine with 12% alcohol content.
? ? A bar glass (about 30 ml) with 40% alcohol content.
This article is only for drug health education, and should not be used as a basis for diagnosis and treatment.
Dear friends, if you have any medical problems, you can contact me privately: tadatw, check or buy, or go to Sharp Daily Ingot Pharmacy:
